Below is a list of selected publications from members of the Early Cancer Institute. For further information on publications by specific Institute researchers, please view their personal profiles.
Extrachromosomal DNA in the cancerous transformation of Barrett’s oesophagus
Luebeck J, Ng AWT, Galipeau PC, Li X, Sanchez CA, Katz-Summercord AC, Kim H, Jammula S, He Y, Lippman SM, Verhaak RGW, Maley CC, Alexandrov LB, Reid BJ, Fitzgerald RC, Paulson TG, Chang HY, Wu S, Bafna V, Mischel PS.
Nature 616, 798–805 (2023). https://doi.org/10.1038/s41586-023-05937-5
Senescence-induced endothelial phenotypes underpin immune-mediated senescence surveillance
Yin K, Patten D, Gough S, de Barros Gonçalves S, Chan A, Olan I, Cassidy L, Poblocka M, Zhu H, Lun A, Schuijs M, Young A, Martinez-Jimenez C, Halim T, Shetty S, Narita M*, Hoare M* * Co-corresponding authors
Genes and Development, 2022, 36(9-10):533-549. May 1; 36(9-10):533-549. https://doi.org/10.1101/gad.349585.122
Substitution mutational signatures in whole-genome–sequenced cancers in the UK population
Degasperi A, Zou X, Dias Amarante T, Martinez-Martinez A, Koh GCC, Dias JML, Heskin L, Chmelova L, Rinaldi G, Wang VYW, Nanda AS, Bernstein A, Momen SE, Young J, Perez-Gil D, Memari Y, Badja C, Shooter S, Czarnecki J, Brown MA, Davies HR, Nik-Zainal S.
Science, 22 Apr 2022. Vol 376, Issue 6591. https://doi.org/10.1126/science.abl9283
Activatable senoprobes and senolytics: Novel strategies to detect and target senescent cells
Morsli S, Doherty GJ, Muñoz-Espín D
Mech Ageing Dev. 2022 Mar;202:111618. https://doi.org/10.1016/j.mad.2021.111618
The evolutionary dynamics and fitness landscape of clonal hematopoiesis
Watson CJ, Papula AL, Poon GYP, Wong WH, Young AL, Druley TE
Science 367 (6485), 1449-1454. https://doi.org/10.1126/science.aay9333
Use of a Cytosponge biomarker panel to prioritise endoscopic Barrett’s oesophagus surveillance: a crosssectional study followed by a real-world prospective pilot
Pilonis ND, Killcoyne S, Tan WK, O’Donovan M, Malhotra S, Tripathi M, Miremadi A, Debiram-Beecham I, Evans T, Phillips R, Morris DL, Vickery C, Harrison J, di Pietro M, Ortiz-Fernandez-Sordo J, Haidry R, Kerridge A, Sasieni PD, Fitzgerald RC
Lancet Oncology 2022, 23:270-78. https://doi.org/10.1016/S1470-2045(21)00667-7
Cellular senescence in cancer: from mechanisms to detection
Ou HL, Hoffmann R, González-López C, Doherty GJ, Korkola JE, Muñoz-Espín D
Genes and Development, 2022, 36(9-10):533-549. https://doi.org/10.1101/gad.349585.122
Resolving the immune landscape of human prostate at a single-cell level in health and cancer
Tuong ZK, Loudon KW, Berry B, Richoz N, Jones J, Tan X, Nguyen Q, George A, Hori S, Field S, Lynch AG, Kania K, Coupland P, Babbage A, Grenfell R, Barrett T, Warren AY, Gnanapragasam V, Massie C, Clatworthy MR
Cell Rep. 2021;37(12):110132. https://doi.org/10.1016/j.celrep.2021.110132
Convergent somatic mutations in effectors of insulin signalling in chronic liver disease
Ng SWK, Rouhani FJ, Brunner SF, Brzozowska N, Aitken SJ, Yang M, Abascal F, Moore L, Nikitopoulou E, Chappell L, Leongamornlert D, Ivovic A, Robinson P, Butler T, Sanders A, Williams N, Coorens THH, Teague J, Raine K, Butler AP, Hooks Y, Wilson B, Birtchnell N, Naylor H, Davies SE, Stratton MR, Martincorena I, Rahbari R, Frezza C, Hoare M*, Campbell PJ*
* Co-corresponding authors
Nature, 2021, 598 (7881) 473-478. https://doi.org/10.1038/s41586-021-03974-6
Molecular phenotyping reveals the identity of Barrett’s esophagus and its malignant transition
Nowicki-Osuch K, Zhuang J, Jammula S, Vleaney CW, Mahbubani KT, Devonshire G, Katz-Summercorn A, Eliing N, Wilbrey-Clark A, Madissoon E, Gamble J, Di Pietro M, O’Donovan M, Meyer KB, Saeb-Parsey K, Sharrocks A, Teichmann SA, Marioni JC, Fitzgerald RC
Science, 2021 373; 760-767. https://doi.org/10.1126/science.abd1449
Triage-driven diagnosis of Barrett’s esophagus for early detection of esophageal adenocarcinoma using deep learning
Gehrung M, Crispin-Ortuzar M, Berman AG, O’Donovan M, Fitzgerald RC, Markowetz F
Nat Med, 2021 May;27(5):833-841. https://doi.org/10.1038/s41591-021-01287-9
Cellular senescence in cancer: from mechanisms to detection
Ou HL, Hoffmann R, González-López C, Doherty GJ, Korkola JE, Muñoz-Espín D
Mol Oncol. 2021 Oct;15(10):2634-2671. https://doi.org/10.1002/1878-0261.12807
COX2 regulates senescence secretome composition and senescence surveillance through PGE 2
Gonçalves S, Yin K, Ito Y, Chan A, Olan I, Gough S, Cassidy L, Serrao E, Smith S, Young A, Narita M, Hoare M.
Cell Rep 2021 Mar 16;34(11):108860. https://doi.org/10.1016/j.celrep.2021.108860
Genomic copy number predicts esophageal cancer years before transformation
Killcoyne S, Gregson E, Wedge DC, Woodcock DJ, Eldridge MD, de la Rue R, Miremadi A, Abbas S, Blasko A, Kosmidou C, Januszewicz W, Jenkins AV, Gerstung M, Fitzgerald RC
Nat Med, vol.26, pages1726–1732, 2020 Sep 7. https://doi.org/10.1038/s41591-020-1033-y