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Early Cancer Institute

ACED Clinical Research team

The mission of ACED Clinic Cambridge is to provide world-leading resources for all Alliance Centres to enable first-in-human clinical trials for early cancer detection to establish feasibility, acceptability and cost effectiveness of new diagnostics and early interventions.

Researchers across the Alliance can apply to work with the ACED Clinical Research team, accessing a range of resources and facilities to accelerate the translation of early cancer detection tests into patient benefit. ACED Clinic Cambridge is hosted in the NIHR Cambridge Clinical Research Facility at Cambridge University Hospital.

Resources include expertise in clinical project coordination, clinical trial statistics, health economics and the regulatory landscape. In addition to providing advice, our team includes research nurses and has the capacity to run single-centre trials.
Facilities include consulting rooms, dedicated outpatient ward space, sample preparation rooms, a fully equipped procedure and endoscopy room, ultrasound equipment and a dark room for ex-vivo imaging.

ACED Cohort

Alongside supporting early-stage trials across the Alliance, the ACED Clinical Research team is recruiting volunteers into a pre-consented ACED Cohort with longitudinal data and sample capture for early detection studies that will be made accessible to the Alliance. We are building value in the ACED Cohort biobank by annual sampling and as such we anticipate that longitudinal samples will not be released before late 2024. However, we will be describing the sample access request procedure for interested researchers on this page in due course.

For more information about participating, visit the ACED Cohort website.


Current trials that are working with ACED Clinic Cambridge include:

LEGACY: Longitudinal Evaluation of the Growth and Acquisition of Clones over Years in the blood (Primary contact: Dr Caroline Watson)
PROSPERO: Prospective multicentre study to identify diagnostic key performance indicators in upper GI endoscopy (Primary Contact: Dr Massimiliano Di Pietro)


ELECTRIC: Use of platelet transcriptomic signatures in the early detection of renal cell carcinoma (Primary Contact: Dr James Whitworth)
EDUCAM: Early detection of neurological malignancy based on cognitive function and cfDNA (Primary Contact: Mr Richard Mair)
PAI-SKINTONE:  Study to establish how skin tone can affect quantitative optoacoustic imaging technology (Primary contacts Mr Amit Roshan, Prof Sarah Bohndiek)
PAGER: Identification of individuals at risk of developing leukaemias to help implement a novel early detection programme for blood cancers (Primary contact Prof George Vassiliou)

Past trials that have been completed:

ANTHCED: An anthropological study of the early detection of cancer (Primary contact: Dr Ignacia Arteaga)
DELTA: Cytosponge implementation research incorporating digital pathology and economic considerations (Primary Contact: Prof Rebecca Fitzgerald)
PAN: Early detection of biomarkers in multiple cancers (Primary Contacts: Prof Rebecca Fitzgerald, Dr Marc van der Schee)

To discuss access to ACED Clinic Cambridge, please contact the ACED Clinical Research team in the first instance with a view to discussing your project prior completing this application form.