Submitted by Catherine Atkins on Mon, 22/05/2023 - 15:02
The Cambridge team behind Cytosponge – the 'sponge on a string' which identifies people at risk of oesophageal cancer – is expanding its work in the UK and beyond following a £13.4 million investment. More than 15,000 NHS patients have already benefited from the Cytosponge test in more than 80 primary and community care sites across the UK.
The new financing includes a £3.4 million NHS Cancer Programme grant provided with the support of SBRI Healthcare. The rest is made up of both equity and grant funding for cancer diagnostic technology, co-led by BGF and Morningside Ventures.
How does the Cytosponge work?
Cytosponge is a small coated pill on a string that contains a sponge. It’s easy for people to swallow, and when the pill reaches the stomach, the coating dissolves and the sponge expands. When the sponge is pulled back up, it collects some of the cells lining the oesophagus on its way. The cells collected are sent off for analysis in the lab, where a simple antibody test called TFF3 is carried out by pathologists, which can easily spot the signs of a precancerous condition called Barrett’s oesophagus.
The new funding has been raised by Cyted, a company founded by the team that created Cytosponge, including Professor Rebecca Fitzgerald OBE and Dr Marcel Gehrung, both from the University of Cambridge.
"Early stage cancer is a major global health issue, and we believe that our technology has the potential to make a real difference in the lives of even more patients and their families." Said Dr Marcel Gehrung.
As an early cancer diagnostics company, Cyted is a prime example of bringing ground-breaking science to industry. The company’s innovative diagnostic platform combines a non-invasive test with data-driven biomarkers for early detection and risk stratification of cancers and inflammatory diseases. The new funding will be used to scale up existing markets, as well as entering the US market, and continuing Cyted’s research and development programmes. It will also support the further expansion of Cytosponge testing to NHS patients in primary and community care settings in the East of England, Lancashire and the Wessex NHS region.
It follows a £500,000 grant from SBRI Healthcare in Spring 2022 for a separate project providing community testing in the North-West of England. Lucy Edwardes Jones from BGF said: "Cyted is one of the most innovative companies at the intersection of diagnostics and cancer. Cyted is addressing a real-world issue with a simple and scalable solution.
"Their technology is already being used across the UK health system with the potential to have a significant impact on patients around the world.”
More about oesophageal cancer
Oesophageal cancer is a global public health priority, with late diagnoses and long waiting times for endoscopies leading to poor survival rates. Earlier diagnosis and better monitoring of Barrett’s oesophagus patients, who are at higher risk of developing oesophageal cancer, can help ensure that cancer is caught early and treated.
Liz Chipchase explains how Cytosponge helped save her life. https://www.youtube.com/embed/C52e2Qz1HOM
By identifying cancer in its earliest stages, the Cystosponge test helps to reduce the number of unnecessary endoscopies, has the potential to significantly improve patient outcomes and save lives – and is already doing so.
Professor Rebecca Fitzgerald's work in research and technological innovation to detect cancer earlier underpins the vision of the Cambridge Cancer Research Hospital. The new state-of-the-art facility will house three world-leading research institutes focused on early detection, integrated cancer medicine and precision breast cancer medicine.
Listen to our Centre podcast episode with Cyted co-founder Dr Marcel Gehrung
Find out more about how the Cytosponge works and the Cytosponge BEST3 trial