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Early Cancer Institute


The new seminar series from the Early Cancer Institute aims to connect researchers in the early cancer detection and diagnosis space to share knowledge and spark collaboration. Join fellow researchers for lunch and an opportunity to network.

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In December our speaker is Angela Goncalves from DKFZ Heidelberg, Germany. Angela's somatic evolution and early detection lab aims to understand how mutant clones arise and expand during the stages preceding the development of malignancy. They combine experimental approaches with bioinformatic analyses and statistical modelling to study these early stages, with a long-term view of improving early detection of cancer.

Angela will speak on: Somatic evolution during ageing and carcinogenesis

Speaker biography

Angela Goncalves trained as a computer scientist at the University of Coimbra in Portugal. Following a stay at the European Space Agency, Angela received a fellowship to study for a PhD at the European Bioinformatics Institute and obtained her PhD from the University of Cambridge in 2012. During her PhD  she investigated the evolution of gene expression regulation during mammalian speciation and developed some of the earliest bioinformatics methods for the analysis of RNA-sequencing data. After her PhD, Angela conducted her postdoctoral research on population genomics at the Wellcome Trust Sanger Institute. In 2017 she was awarded a Pump Priming grant by the Cambridge Cancer Centre Early Detection Programme to establish the use of menstrual fluid as a model system to track somatic mutations in normal tissues over time. Since 2018 she has led a group at the German Cancer Center. Her research interests are in modelling the evolution of somatic mutant clones in normal and pre-malignant tissues, with the view of developing methods for preventing and detecting cancer early.

Speaker webpage.


Register for the event here:

Thursday, 8 December, 2022 - 12:30 to 14:00
Event location: 
Clifford Allbutt Building, Cambridge Biomedical Campus, CB2 0XY